Drugs Looks Promising for Alzheimer's disease

More than 6 million Americans have Alzheimer's disease and well over 10 million baby boomers are expected to develop it in the coming years, which is why there's so much excitement about research being presented this week at a major conference of Alzheimer's experts.

New pill may restore memory loss in less than four weeks.
Dr. Marie Savard, boiled down some of the new developments that will be discussed at the conference.

Alzheimer's can be caused by the build-up of plaque in the brain and by fibrous tangles which wrap around nerve cells in the brain and kill the cells. Previous drugs have attacked the plaque, not very successfully.

A study was published recently that showed a drug called AL 108, which is actually a new type of nasal spray, attacks those fibrous tangles. Patients given AL 108 showed significant improvement in short-term memory after just four weeks and exhibited no side effects.

Testing of the drug is in early phase 2 trials, so a cure is not around the corner and there is no cure right now, but many researchers are excited about the findings.

Researchers at the conference will also present information about a powerful new test to detect Alzheimer's using PET scans.

PET scans have been very useful in detecting early-stage cancer, and researchers hope this new test could detect Alzheimer's as early as 10 years before people show symptoms of the disease, allowing them to begin treatment earlier.

The PET scan tests for Alzheimer's could be approved by the Food and Drug Administration in the next three or four years. PET scans are already widely used in hospitals to test for cancer and other diseases.

Antihistamine Looks Promising for Alzheimer's Patients
Alzheimer's disease can be heartbreaking to watch and frustrating to treat. Most medicines on the market do little more than delay the inevitable mental decline.

Preliminary tests show that Dimebon helps in restoring some memory.
But a new drug called Dimebon appears to stop and perhaps even reverse the symptoms of the cruel and degenerative disease, according to a new study published in the journal Lancet today.

"I was pleasantly surprised to see the effect on cognitive function, on memory, on activities of daily living that not only were clearly significant but seemed to increase over time," said Dr. Sam Gandy, former chairman of the Alzheimer's Association Medical and Scientific Advisory Council.

Dimebon wasn't designed to treat Alzheimer's disease. Far from it. It's an antihistamine that was supposed to treat allergies.

But a study that tracked 120 mild to moderate Alzheimer's patients for a year, and found that at six months those taking Dimebon three times a day showed significant improvement in mental tests and cognitive functioning, while those placed on the placebo kept deteriorating. A year into the study, the Dimebon group was still improving, while those without the drug were declining rapidly.

Hopes Dashed for Alzheimer's Drug
Researchers Abandon Flurizan; Doctors Hold Out Hope for Effective Approach
Many Alzheimer's researchers deny that the failure of a promising remedy for the degenerative disease requires a return to the drawing board, saying the setback is not a death knell for drugs designed to target a protein in the brain considered the trigger for the disease.

Still, doctors are disappointed that the treatment fell short of expectations -- especially when its makers spent $60 million on it during the past year alone.

On June 30, Myriad Genetics Inc. announced that its drug Flurizan didn't improve cognitive function or performance of daily activities for people who have Alzheimer's disease. A recent clinical trial tested the drug for 18 months in patients with a mild form of the condition.

"We are disappointed that Flurizan failed to achieve significance in this study, and we will now discontinue development of this compound," Myriad's CEO Peter Meldrum said in a statement.

Flurizan targeted one type of protein in the brain called beta amyloid. Researchers believe that the protein forms clumps that clog the connections between brain cells, which may contribute to the symptoms of Alzheimer's, which include progressive memory loss.

It was hoped that Flurizan would decrease the production of beta amyloid and slow the progression of the disease.

However, many scientists say they were not surprised by the findings. In fact, they say they even expected the outcome after seeing the underwhelming results of an earlier trial of the drug.

"The bottom line is that Flurizan was a nonstarter from the very beginning," says Rudy Tanzi, professor of neurology at Harvard Medical School in Boston. Tanzi is also the co-founder and shareholder of two companies that develop Alzheimer's treatments.

When results released in 2006 did not show an overall positive effect of Flurizan on brain function, Myriad researchers narrowed the patient population to target a small subgroup of people who benefited from the drug. They used this population -- patients who had mild Alzheimer's disease and took a high dose of the drug -- in the most recent trial.

But by that time, the earlier trial had already "cast considerable doubt on the potency of the drug in Alzheimer's disease," says Dr. Sid Gilman, director of the Michigan Alzheimer's Disease Research Center in Ann Arbor, Michigan...

"I have been skeptical of this all along," Gilman added.

Where to Go From Here
Doctors say that this latest defeat in the fight against Alzheimer's gives no indication of the state of research relating to the disease.

"Flurizan was the first shot on goal, but it was a shot from the 50-yard-line by a fifth grader," Tanzi says. "This is by no means a failure of all drugs that target amyloid beta."

Dr. Ronald Petersen, director of the Alzheimer's Disease Treatment Center at the Mayo Clinic in Rochester, Minn., agrees and says, "There are many other alternatives in the pipeline that show promise."

Among these are drugs aimed at various targets, Gilman says, including the immune system, receptors for various chemicals that bathe brain cells, and other pathways for stopping the pesky proteins that researchers believe contribute to Alzheimer's symptoms.

But treating and curing the condition may require a tag team of therapies to achieve the most effective results.

"I suspect that the reality is that attacking the amyloid cascade is a complicated issue, and no single therapeutic strategy is likely to be the final answer," Petersen says.

Scientists are optimistic that even with Flurizan's demise, a plausible treatment will emerge soon.

"History has shown that when you have a new mechanism and a new target, inevitably the first wave of drugs is usually the worst," Tanzi says, referring to the findings from Flurizan. "In these situations you need to be patient and wait for the second or third wave of drugs. ... That wave is coming."

There are still no CURE of any kind for Alzheimer's disease today on the world market... Dr.William Thomas.

Mary Joseph Foundation a non-profit organization for Alzheimer's disease.
137 1/2 Washington Ave, Suite 292
Belleville, NJ 07109
201-336-0075

How and why we raise funds.

The services Mary Joseph Foundation provides to raise funds for individuals who have Alzheimer's disease and young hungry children here and around the world.

( 1 ) We do Consulting and Lecturing on Security, Security, Network and Design Engineering, international Law and Constitutions to Governments and Businesses around the world.

( 2 ) We give talks on Security, Energy, Medicines, Religion, Engineering, Politics and international public relations.

( 3 ) We develop and sell our products for memory and Brain, to help individuals avoid getting Dementia/Alzheimer's.

To all Governments, Businesses and Universities here in America and around the world, I hope that we at the Mary Joseph Foundation a non-profit organization will get the chance to provide our services to your institutions, now and in the future.

All of our speakers and lecturers are expert in their fields, they are political and fortune 500 corporations leaders from around the world.

Over 90 percent of all funds raise from speaking, consulting and lecturing goes to helping individuals who have Alzheimer's disease and young children who are hungry here and many third world countries. We provides rooming, foods, vitamins, medicines and caring for individuals with Alzheimer's disease especially those who are living in homes for the insane and crazy, on the street and homeless, we also provide foods for young hungry children especially in the third world countries. Mary Joseph Foundation provides all these services for FREE.

Please support us in our non-profit work, there is always a greater happiness in giving than in receiving. We are always looking for partners to work with especially in the third world countries.

www.maryjosephfoundation.org

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Fred Joseph

President

Former senior security engineer Citi Bank, JP MorganChase, IBM and the Federal Government.

137 1/2 Washington Ave, Suite 292, Belleville, New Jersey 07109

The loving letter to all Americans that make me cry.

Letter from President Ronald Reagan to the American people:
Nov. 5, 1994

My Fellow Americans,

I have recently been told that I am one of the millions of Americans who will be afflicted with Alzheimer’s disease.

Upon learning this news, Nancy and I had to decide whether as private citizens we would keep this a private matter or whether we would make this news known in a public way.

In the past, Nancy suffered from breast cancer and I had my cancer surgeries. We found through our open disclosures we were able to raise public awareness. We were happy that as a result, many more people underwent testing.

They were treated in early stages and able to return to normal, healthy lives. So, now we feel it is important to share it with you. In opening our hearts, we hope this might promote greater awareness of this condition. Perhaps it will encourage a clearer understanding of the individuals and families who are affected by it.

At the moment I feel just fine. I intend to live the remainder of the years God gives me on this earth doing the things I have always done. I will continue to share life’s journey with my beloved Nancy and my family. I plan to enjoy the great outdoors and stay in touch with my friends and supporters.

Unfortunately, as Alzheimer’s disease progresses, the family often bears a heavy burden. I only wish there was some way I could spare Nancy from this painful experience. When the time comes I am confident that with your help she will face it with faith and courage.

In closing, let me thank you, the American people, for giving me the great honour of allowing me to serve as your President. When the Lord calls me home, whenever that may be, I will leave with the greatest love for this country of ours and eternal optimism for its future.

I now begin the journey that will lead me into the sunset of my life. I know that for America there will always be a bright dawn ahead.

Thank you, my friends. May God always bless you.

Sincerely,

Ronald Reagan

I will always LOVE you.

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Mary Joseph Foundation a non-profit organization for Alzheimer's

Alois Alzheimer

Alois Alzheimer was born in 1864 in Markbreit in Bavaria, Southern Germany. Excelling in sciences at school he studied medicine in Berlin, Aschaffenburg Tubingen and Wurzburg where he graduated with a medical degree in 1887. He began work in the state asylum in Frankfurt am Main, becoming interested in research on the cortex of the human brain. Here he commenced his education in psychiatry and neuropathology.

Along with Franz Nissl, a colleague at the asylum, Alzheimer spent the following years working on a major six volume study, the 'Histologic and Histopathologic Studies of the Cerebral Cortex,' describing the pathology of the nervous system. The work was finally published between 1907 and 1918. In 1895 Alzheimer was appointed director of the asylum where he continued his research on a number of subjects including manic depression and schizophrenia.

Today, the pathological diagnosis of Alzheimer's disease is still generally based on the same investigative methods used in 1906. This is remarkable compared with the development of investigative methods for other diseases, and it speaks volumes about the quality of Alzheimer's discovery.

Alzheimer's disease is the most common cause of dementia and accounts for 65% - 80% of all cases. It destroys brain cells and nerves disrupting the transmitters which carry messages in the brain, particularly those responsible for storing memories. Alzheimer's disease was first described by A. Alzheimer's in 1906.

During the course of Alzheimer's disease, nerve cells die in particular regions of the brain. The brain shrinks as gaps develop in the temporal lobe and hippocampus, which are responsible for storing and retrieving new information. This in turn affects people's ability to remember, speak, think and make decisions. The production of certain chemicals in the brain, such as acetylcholine is also affected. It is not known what causes nerve cells to die but there are characteristic appearances of the brain after death. In particular, 'tangles' and 'plaques' made from protein fragments are observed under the microscope in damaged areas of brain. This confirms the diagnosis of Alzheimer's disease.

Currently there are over 18 million peoples worldwide who are living with Alzheimer’s disease and that number is expected to grow to as many as 71 million by 2025. Alzheimer’s disease is the seventh leading cause of death in the United States and number six worldwide.

Mary Joseph Foundation for Alzheimer's disease

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New Report Says over 10 Million Americans Will Develop Alzheimer's disease in the near future

Every 22 seconds in the world and every 71 seconds in this country, someone is diagnosed with Alzheimer's disease, and a startling new report out today from the Alzheimer's Association predicts that one out of every eight baby boomers — or almost 10 million Americans — is expected to develop the disease sometime in the near future. If new treatments are years away, is there anything you can do today that might prevent it?

Fran Hershkowitz's mother began losing her memory more than a decade ago, and now Fran, who is 63, worries if he might be next.

"It's frightening, too, to think that one day this is going to be me." the younger Hershkowitz said. Evidence shows that physical exercise may be the most effective remedy today to prevent Alzheimer's disease, and large health studies have shown that people who stay physically active are less likely to develop the disease. Scientists put that idea to the test. Researchers bred mice to develop the specific kind of plaque in the brain, as seen in Alzheimer's disease. Some mice were allowed to exercise, and some were not. The autopsy results were stunning.

The brains of sedentary mice were riddled with the harmful plaques, but the physically active mice had 50 to 80 percent less plaque. Further tests revealed that the mice who exercised produced twice as much of an enzyme in the brain that prevents plaque buildup. The exercise also produced twice as many tiny blood vessels in the brain to allow plaques to escape. "Moving plaques from the brain into the blood, so it's carried to those organs like the liver where it can be destroyed," said Professor Sangram S. Sisodia, a neuroscientist at the University of Chicago and lead investigator in the study. Population studies suggest any exercise that raises your heart rate for 30 to 45 minutes at least several times a week can lower your risk of Alzheimer's. And the more the exercise you get, the lower your risk. "Regular physical exercise is probably the best means we have of preventing Alzheimer's disease today," said Dr. Ronald Petersen, director of the Alzheimer's Research Center at the Mayo Clinic in Rochester, Minn.

"There are other possible intervention, including diet, and supplements, intellectual activities, but the data indicate that physical activity is the most likely to prevent this disease," Doctor William Thomas said. For family members determined to avoid another generation of this disease, there is finally preventative action they can take, which they won't have to wait for.

"Regular physical exercise is probably the best means we have of preventing Alzheimer's disease today." Dr. Ronald Petersen of the Mayo Clinic Alzheimer's Disease Research Center said. "Better than medications, better than intellectual activity, better than supplements and diet."

For family members determined to avoid another generation of this disease, there is finally preventative action they can take, which they won't have to wait for.

www.maryjosephfoundation.org

Mary Joseph Foundation a non-profit organization for Alzheimer's disease.
137 1/2 Washington Ave, Suite 292, Belleville, NJ 07109.

http://www.miltilinkwithpeoplesandcorporations.blogspot.com/

http://www.marycharityfoundation.blogspot.com/

A world without Alzheimer's and hungry Children.

We really cares about you!

Our main gold is to eliminate Alzheimer's disease through the advancement of research; at the same time to provide and enhance care and support for all affected by this disease; and to reduce the risk of dementia through the promotion of brain health. We are working very hard so that one day there would be a world without Alzheimer's disease, but for now with your donations its allow us to build homes, give medicines, foods, vitamins, caring and remove individuals who have Alzheimer's disease from the street who are homeless and from mental homes and cares for them, our services are FREE.

It hurt me very, very much that tears some times come to my eyes to see so much people here in America and around the world suffering from Alzheimer's disease and the children who go with out foods and many times are homeless.

Mary Joseph Foundation cares and we are doing everything possible to eliminate Alzheimer's disease, homelessness and hunger.

We are looking for more companies to work with us on Alzheimer's disease and children who are hungry and homeless.

To help please send all mails and donations to: Mary Joseph Foundation a non-profit organization, 137 1/2 Washington Ave, Suite 292, Belleville, NJ 07109
website www.maryjosephfoundation.org

Melrose Joseph
Director

Special project 81-49222-005A 2009

We have come along way and I want to personally thank each and everyone of you for your support and tell you how important it is.With early onset of Alzheimer's detection and treatment the chance of slowing it down is much greater.As a special program of the Alzheimer's Foundation for detection of symptoms and prevention the mission of the Alzheimer's assistance relief fund is to support educational, prevention, medical assistance and relief, and innovative research programs in order to reduce the incidence of early onset of Alzheimer's disease in America and throughout the rest of the world.The Alzheimer's assistance relief fund is also fully committed to directly assisting patients, and caregivers with the personal devastation caused by Alzheimer's disease.

There are still no CURE of any kind for Alzheimer's disease today on the world market... Dr.William Thomas.

Thank you for your generous support, your gifts of $1.00 --$2.00 --$5.00 and $10.00, it provides and continue to provide another step closer to finding a CURE for Alzheimer's and at the same time helping those who have Alzheimer's disease, chance for life.

For every ten dollars $25 donation or more you make to the Alzheimer's assistance relief fund, you will get a gift from us that value upward of $20.000 in saving on food...We just want to say thank for your support.

Just by sending $1.00 or $2.00 it would be very, very much appreciated.With my humble and deepest gratitude,

Melrose Joseph,
Director for special needs

Please make check or money order payable to:
Mary Joseph Foundation for Alzheimer's disease
137 1/2 Washington Ave, Suite 292
Belleville, NJ 07109.
201-336-0075
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